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Effect of Modified Ultrafiltration on Interleukin-6,-Interleukin-8 and TNF-alpha Levels in Pediatric Cases with Endocardial Cushion Defects Undergoing Cardiopulmonary Baypass
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Research Article
VOLUME: 1 ISSUE: 2
P: 62-69
August 2023

Effect of Modified Ultrafiltration on Interleukin-6,-Interleukin-8 and TNF-alpha Levels in Pediatric Cases with Endocardial Cushion Defects Undergoing Cardiopulmonary Baypass

Turk J Clin Cardiov Perfusion 2023;1(2):62-69
DOI: 10.4274/tjccp.galenos.2023.83007
Edanur Akpınar 1
Nazan Atalan Özlen 2
Nilgün Kansak 3
Hilal Can 1
Tayfun Solak 1
Numan Ali Aydemir 4
Sinan Arsan 5
1. Marmara Üniversitesi Sağlık Bilimleri Enstitüsü, Perfüzyon Bilim Dalı, İstanbul, Türkiye
2. Marmara Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, İstanbul, Türkiye
3. Sağlık Bilimleri Üniversitesi, Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, Tıbbi Mikrobiyoloji Kliniği, İstanbul, Türkiye
4. Sağlık Bilimleri Üniversitesi, Dr. Siyami Ersek Göğüs Kalp ve Damar Cerrahisi Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, İstanbul, Türkiye
5. Marmara Üniversitesi Tıp Fakültesi, Kalp ve Damar Cerrahisi Anabilim Dalı, İstanbul, Türkiye
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Received Date: 20.06.2023
Accepted Date: 01.08.2023
Publish Date: 15.08.2023
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ABSTRACT

Objective:

The aim of this study was to determine the effect of modified ultrafiltration (MUF) on interleukin (IL)-6, IL-8, and tumor necrosis factor-alpha (TNF-α) levels in pediatric patients with atrial, ventricular, and atrioventricular septal defects undergoing cardiopulmonary bypass (CPB).

Materials and Methods:

In the study, pediatric cases under 3 years of age, weighing less than 10 kg, with endocardial cushion defects scheduled for elective open heart surgery were randomly divided into two groups: MUF applied (group 1, n=17) and MUF not applied (group 2, n=17). All cases received ultrafiltration after CPB, and IL-6, IL-8, and TNF-α levels were compared at 24 h postoperatively. Demographic characteristics, hemodynamic and laboratory values, and clinical parameters during the 24-hours postoperative follow-up were recorded for all cases. data were analyzed using SPSS 22.0 software.

Results:

No statistically significant difference was observed in the comparison of IL-6, IL-8, and TNF-α levels between the groups.

Conclusion:

This study found that the application of MUF did not result in a significant difference in IL-6, IL-8, and TNF-α levels compared with patients without MUF. Further studies with similar designs are recommended to better evaluate the results.

Keywords:
Cardiopulmonary bypass, cytokine, modified ultrafiltration

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