Abstract
It is aimed to understand what the goal directed perfusion parameters are, which gained importance in the perfusion field in the 2010s and changed the perspective on perfusion, and the formulas used in making these calculations of heart-lung machines and extracorporeal membrane oxygenation devices that calculate and measure the new generation goal directed perfusion parameters, which have become widespread in the recent period.
Keywords: Goal directed perfusion, SaO2, PaO2, DO2, VO2, VCO2, O2Er, SVO2
References
Young RW. Hyperoxia: a review of the risks and benefits in adult cardiac surgery. J Extra Corpor Technol. 2012;44(4):241-249.
Smit B, Smulders YM, van der Wouden JC, Oudemans-van Straaten HM. Hemodynamic effects of acute hyperoxia: a systematic review and meta-analysis. Crit Care. 2018;22(1):45.
O’Driscoll BR, Howard LS, Earis J, Mak V. BTS guideline for oxygen use in adults in healthcare and emergency settings. Thorax. 2017;72(Suppl 1):ii1-ii90.
Kacmarek RM, Hess DR. Arterial blood gas interpretation in clinical practice. In: principles and practice of mechanical ventilation. 3 rd ed. New York: McGraw-Hill; 2012.
Arterial blood gas ınterpretation in clinical practice. 1 st ed. New York: Springer, 2021
Murphy GS, Hessel EA 2 nd , Groom RC. Optimal perfusion during cardiopulmonary bypass: an evidence-based approach. Anesth Analg. 2009;108(5):1394-417.
Mitrev L, Krickus C, DeChiara J, Huseby R, Desai N, van Helmond N. Association of preoperative pulse pressure and oxygen delivery index during cardiopulmonary bypass with postoperative acute kidney injury. J Cardiothorac Vasc Anesth. 2022;36(11):4070-4076.
Parolari A, Alamanni F, Gherli T, Bertera A, Dainese L, Costa C, et al. Kardiyopulmoner baypas ve oksijen tüketimi: oksijen iletimi ve hemodinamik. Gogus Cerrahisi Yilliklari. 1999;67(5):1320-1327.
Wasserman K, Hansen JE, Sue DY, Stringer WW, Whipp BJ. Principles of exercise testing and interpretation. 4 th ed. Philadelphia: Lippincott Williams & Wilkins; 2005.
Pybus DA, Lyon M, Hamilton J, Henderson M. Measuring the efficiency of an artificial lung: 1. Carbon dioxide transfer. Anaesth Intensive Care. 1991;19(3):421-443.
Dijoy L, Dean JS, Bistrick C, Sistino JJ. The history of goal-directed therapy and relevance to cardiopulmonary bypass. J Extra Corpor Technol. 2015;47(2):90-94
Sahlin K, Harris RC, Nylind B, Hultman E. Extracellular bicarbonate and non-bicarbonate buffering against lactic acid during and after exercise. Eur J Appl Physiol. 2007;100(4):457-467.
Rafieian-Kopaei M, Nasri H. What are the minimal criteria of goal-directed perfusion (GDP) in adult cardiac surgery? Connect. 2024;S1:1.
Zhang Y, Xiong H, Wang B, Luo M, Liu T, Qin Z, et al. Carbon dioxide production index (VCO 2 i) predicts hyperlactatemia during cardiopulmonary bypass in pediatric cardiac surgery (pGDP-VCO 2 i): Study protocol for a nested case-control trial. Perfusion. 2025;40(1):157-163.
Al Awawdeh A, Iafrate M, Giovinazzo G. What are the minimal criteria of goaldirected perfusion (GDP) in adult cardiac surgery? QScience Connect. 2024;2024(1):1.
Ranucci M. Carbon dioxide production during cardiopulmonary bypass: pathophysiology, measure and clinical relevance. Perfusion. 2016(1);1-9.
Mongero LB, Beck JR, eds. On bypass: advanced perfusion techniques. 1 st ed. New York: SCC; 2008.
